|
|
2,5-二羥基苯乙酮 |
| CAS No.: |
490-78-8 |
| 分子式： |
C8H8O3 |
| 分子量： |
152.15 |
| 備注： |
中文名稱2,5-二羥基苯乙酮中文同義詞2’,5’-二羥基苯乙酮;2,5-二羥基乙酰苯;2,5-二羥苯乙酮;2-乙醯氫醌;2,5-二羥基苯乙酮;2’,5’-二羥基苯乙酮,98+%;苯乙酮,2’,5’-二羥基-;乙酮,1-(2,5-二羥苯基)-英文名稱2’,5’-Dihydroxyacetophenone英文同義詞1-(2,5-dihydroxyphenyl)-ethanon;1-Acetyl-2,5-dihydroxybenzene;2,5-Dihydroxy-1-acetylbenzene;2’,5’-dihydroxy-acetophenon;Acetophenone,2’,5’-dihydroxy-;Acetylhydroquinone;QUINACETOPHENONE;2-AcetylhydroquinoneQuinacetophenoneCAS號490-78-8分子式C8H8O3分子量152.15EINECS號207-716-4相關類別苯乙酮;通用試劑;有機砌塊;羰基化合物;酮;其它酚類;合成材料中間體;對照品;BuildingBlocks;C7toC8;CarbonylCompounds;ChemicalSynthesis;FINEChemical&INTERMEDIATES;AromaticAcetophenones&Derivatives(substituted);Ketones;OrganicBuildingBlocksMol文件490-78-8.mol結構式2,5-二羥基苯乙酮性質熔點204-206°C(lit.)沸點234.6°C(roughestimate)密度1.2143(roughestimate)折射率1.4447(estimate)儲存條件Storebelow+30°C.溶解度二惡烷：50mg/mL，透明酸度系數(shù)(pKa)9.86±0.18(Predicted)形態(tài)晶體或結晶粉末顏色黃色至黃綠色水溶解性insolubleBRN637903InChIKeyWLDWSGZHNBANIO-UHFFFAOYSA-NLogP1.274(est)CAS數(shù)據(jù)庫490-78-8(CASDataBaChemicalbookseReference)NIST化學物質信息Ethanone,1-(2,5-dihydroxyphenyl)-(490-78-8)EPA化學物質信息Ethanone,1-(2,5-dihydroxyphenyl)-(490-78-8)2,5-二羥基苯乙酮用途與合成方法生物活性2’,5’-Dihydroxyacetophenone(DHAP,2-Acetylhydroquinone,Quinacetophenone)是二羥基苯乙酮異構體的混合物，用于食品調味。2’,5’-Dihydroxyacetophenone通過抑制iNOS的表達來顯著抑制NO的產(chǎn)生。2’,5’-Dihydroxyacetophenone可通過阻斷ERK1/2和NF-κB信號通路來顯著地降低促炎細胞因子TNF-α和IL-6的表達水平。靶點TargetValueiNOS()ERK1/2()NF-κB()TNF-α()IL-6()體外研究2,5-DihydroxyacetophenonesignificantlyinhibitsNOproductionviathesuppressionofiNOSexpressionandsignificantlydecreaseslevelsofthepro-inflammatorycytokinesTNF-αandIL-6viathedown-regulationoftheirmRNAexpressioninLPS-stimulatedRAW264.7cells.2,5-Dihydroxyacetophenonepotentlyinhibitsthephosphorylationofextracellularsignal-relatedkinase(ERK)1/2andthenucleartranslocationofnuclearfactor-κB(NF-κB)p65inLPS-stimulatedcells.化學性質淡黃綠色針狀結晶。熔點202-203℃。溶于醇，難溶于醚和苯，幾乎不溶于冷水。在堿溶液中呈黃色，遇三氧化鐵呈藍色。能升華。用途用于有機合成。生產(chǎn)方法由對苯二酚二乙酸酯在三氯化鋁存在下反應而得。 |
| 結構式： |
 |
 |
|
聲明：以上信息未經(jīng)本網(wǎng)證實,僅供參考,華夏化工網(wǎng)不承擔任何風險責任. |
|
